To examine relationships ranging from dieting and coronary attack, we made use of Cox proportional problems patterns stratified from the age (mo) and you may pursue-upwards period so you’re able to imagine RRs and you can 95% CIs. Players was indeed divided in to quintiles off collective mediocre intake away from magnesium, potassium, and calcium supplements to reduce the interior-person adaptation and best portray long-title consumption ( 18). A combined nutrient diet get off magnesium, potassium, and you can calcium was indeed determined because of the delegating items to each quintile and you will summing the fresh new items. Participants regarding the lowest quintile (quintile step 1) away from magnesium, potassium, otherwise calcium consumption acquired step 1 part for every nutrient, professionals in the next quintile (quintile 2) obtained 2 activities, and so forth. Collective averages were calculated by using the fresh new imply of all claimed FFQ consumption to the start of for each 2-y pursue-right up period. The newest collective average intake was utilized so you can anticipate coronary attack occurrence out of the amount of time of one’s past came back questionnaire up until the 2nd realize-up stage.
Multivariate patterns was indeed modified getting years (mo) and you can schedule big date (2-y go out durations) and you may incorporated consumption of full opportunity (kcal), alcoholic beverages (g/d), smoking, Body mass index, physical working out, parental reputation of early myocardial infarction, postmenopausal hormonal treatment have fun with, thiazide use, aspirin use, multivitamin explore, and you may reputation of all forms of diabetes, blood pressure levels, and you may hypercholesterolemia in the baseline. To evaluate to have a great linear development, i tasked for every single quintile this new median well worth and you may modeled that it adjustable due to the fact a continuous variable. I checked out the potential deviation from linearity by using a chances ratio test for investigations out of a design towards linear name having a model such as the linear label plus minimal cubic spline transformations ( 19). We together with used analyses one included most of the step 3 nutritional elements additionally. Magnesium and you can potassium consumption was in fact extremely coordinated (r = 0.79 regarding the NHS We; r = 0.73 regarding NHS II), and correlations between calcium supplements and you will potassium consumption (roentgen = 0.44 regarding NHS We; roentgen = 0.41 on NHS II), whereas anywhere between calcium and you will magnesium intakes (roentgen = 0.54 regarding NHS We; roentgen = 0.56 about NHS II) were reasonable. The fresh new Q shot was used to evaluate towards the heterogeneity ranging from new https://datingranking.net/pet-dating/ NHS We and you can NHS II. RRs (±SEs) for each and every quintile out of each cohort was basically pooled from inside the repaired-effects activities to help you calculate summary prices ( 20). Likewise, brand new current meta-analysis adopted practical behavior ( 20) regarding assessment for heterogeneity utilizing the Q make sure using repaired outcomes model to manufacture realization rates when no between-degree heterogeneity is apparent; otherwise an arbitrary-outcomes model was utilized.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
While in the 31 y off follow-right up of 1980 as a consequence of 2010 throughout the NHS We and you will twenty two y off pursue-upwards from 1989 courtesy 2011 from the NHS II, a total of 3780 incident coronary arrest circumstances was basically ascertained. Of those cases, 3237 event shots were recorded regarding the NHS We (including 1664 ischemic, 544 hemorrhagic, and 1029 unspecified shots), and 543 experience strokes were documented about NHS II (plus 186 ischemic, ninety-five hemorrhagic, and you may 265 unspecified shots). Age-standard properties away from analysis players within midpoint during the follow-right up into the 1994 towards NHS I and also in 1995 having new NHS II receive from inside the Table step 1. Girls having higher nutrient intake have been more likely to explore aspirin, vitamins, and you can postmenopausal hormone therapy, much more truly energetic, less likely to want to getting current smokers than just was indeed ladies that have all the way down mineral consumption. Data for females regarding the NHS I and NHS II had been shared due to the fact i don’t observe a serious anywhere between-research heterogeneity (Q-figure P > 0.05).