Spike earliest discovered Drusilla after he was refuted by Cecily; the guy fled the class he had been browsing, and you will sobbed within the the regional alleyway. Drusilla, who’d chose to like an effective playmate, sired him. He expanded enormously connected to her, and later applauded the lady since the “your face away from their salvation.” He had been devastated as he very first stuck Drusilla making love that have Angelus.  Even when their thinking are remaining hardened consequently, the guy handled solid passion on her behalf. When she try leftover in a weaker state an almost-death-run into in the Prague,  he found sanctuary on her around the Sunnydale Hellmouth; their main desire when you look at the remaining in Sunnydale would be to assist the woman recover.
Saddened and envious, Surge was prompted to help you betray Angelus and you can eliminate Sunnydale which have Drusilla in pull.  From inside the Brazil, she duped to the your once more, that have a turmoil devil. However, it actually was later on indicated that Drusilla had separated having him once the through the girl visions she often see their pent up obsession and soon getting know “feelings” having Buffy shortly after the guy helped their within the ending Acathla and can even maybe not endure they whenever most of the she spotted when she checked-out your are this new Slayer.  Surge gone back to Sunnydale later to get a romance potion, but after changed their brain and felt like that torturing their do winnings the lady straight back, regardless if one too unsuccessful. 
A processor-implanted Spike manage later on speak about the lady throughout the a failed suicide try, saying “Goodbye, Dru. View you inside the Hell.”  When discussing their hit a brick wall connection with Drusilla which have Anya Jenkins, Spike stated that they must kill the lovers just like the payback. Although not, when Anya refuted, Increase are reluctant to really share Dru, as he did nonetheless love their.  Whenever Xander got admitted so you’re able to Spike not many people knew his interest in Anya, Surge said he could relate and reminisced more their prior relationships having Drusilla, saying “Nobody previously very had Dru, y’know?” 
Drusilla gone back to Sunnydale regarding hopes of reforming their “household members.” Increase seemed fascinated and chose a few of their feelings for her, briefly choosing to incorporate this lady and have to new method he was. Just after feeding a dead individual and slamming out Buffy, Surge all of a sudden activated Drusilla and fastened her or him one another to come to a decision once and for all. Getting back together his attention rather effortlessly, Spike admitted his will Buffy and you can frantically attempted to encourage the woman it absolutely was genuine. Drusilla quickly chuckled from the your, revealing one to she had identified every collectively the guy adored this lady because the a result of their novel performance. Whenever Buffy nonetheless would not capture his feelings surely, Spike expanded crazy and you can chose to risk Drusilla so she you are going to faith him. Then indicated their turned fondness regarding Drusilla and you will said she meant very much so you can him, stating she “conserved your out of mediocrity.” When you’re Increase was sidetracked of the Harmony, Drusilla been able to put herself 100 % free and you may attacked Buffy (who had been nonetheless chained). Surge removed this lady out of her and you may spared Buffy. Viewing where their loyalties sit, an angry and you will troubled Drusilla threw in the towel to the Increase and you can left, enjoying him given that far too “lost” on her to greatly help your. 
The 2 was indeed briefly reunited when Drusilla are leased of the Wolfram Hart to assist her the brand new mate, John, just who went after Spike inside the distorted religion your vampire had taken their soul.  Initially reluctant to see her, Increase which have understanding one to Dru is poisonous and you can hazardous getting their family members.  Surge following got Willow acknowledge Drusilla toward Mosaic Fitness Center.